Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2115979 | Cancer Letters | 2006 | 5 Pages |
Abstract
Adnab-9 binding in colonic tissue and effluent has been associated with an increased risk for colorectal neoplasia. We investigated if fecal binding by Adnab-9 may be used as a marker for colorectal neoplasia. A fecal-Adnab-9 ELISA was performed on samples of 249 patients and colonoscopic pathology results correlated. Fecal Adnab-9 binding was seen in 63% of patients with colorectal neoplasia (59% with colorectal cancer and 83% with adenoma), 33% with inflammatory bowel disease, 0% with hyperplastic polyps and 10% of controls. We conclude that fecal Adnab-9 binding is a promising risk marker for colorectal neoplasia.
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Authors
Mei Yuan, XiaoPing Xhang, YiaLi Leu, Yi Xu, Nadeem Ullah, Michael Lawson, Martin Tobi,