Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116292 | Cancer Letters | 2013 | 8 Pages |
Abstract
We investigated how near-infrared imaging could improve highly infiltrative spontaneous fibrosarcoma surgery in 12 cats in a clinical veterinary phase. We used an RGD-based nanoprobe at different doses and times before surgery and a portable clinical grade imaging system. All tumours were labelled by the tracer and had an overall tumour-to-healthy tissue ratio of 14 ± 1 during surgery. No false negatives were found, and the percentage of tumour cells was linearly correlated with the fluorescence intensity. All cats recovered well and were submitted to long-term follow-up that is currently on-going 1 year after the beginning of the study.
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Authors
Christiane H.F. Wenk, Frédérique Ponce, Stéphanie Guillermet, Corinne Tenaud, Didier Boturyn, Pascal Dumy, Dorothée Watrelot-Virieux, Claude Carozzo, Véronique Josserand, Jean-Luc Coll,