| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2116402 | Cancer Letters | 2011 | 7 Pages |
Abstract
Metastasis remains a formidable problem in malignant tumors. In this study, MTT assay revealed that 4-methyl-3-nitro-benzoic acid (MNBA) had no effect on cell viability and did not interfere with cell cycle in any breast cancer cell lines tested. However, treatment with MNBA on breast cancer cells can inhibit EGF-induced migration and chemotaxis in vitro. In vivo assay demonstrated that MNBA and Paclitaxel synergistically inhibited tumor growth and metastasis in breast cancer SCID mice xenografts. These results suggest that MNBA is a potent inhibitor cancer cell chemotaxis and may be developed into a novel anti-metastasis drug.
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Hua Guo, Menghui Li, Peng Chen, David J. Blake, Xiaoni Kong, Xishan Hao, Ruifang Niu, Ning Zhang,