Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116506 | Cancer Letters | 2010 | 5 Pages |
Abstract
The effects of surfactants on the disposition kinetics of docetaxel and paclitaxel were examined in tumor-bearing rats. Taxol and Taxotere were administered intraperitoneally to AH130 tumor-bearing rats. Plasma and ascitic AUCs (AUCp,0-24Â h and AUCa,0-24Â h) of paclitaxel were â¼2- and 6-fold larger than those of docetaxel, respectively. The AUCa,0-24Â h,ascite/AUCp,0-24Â h ratio of paclitaxel was â¼3-fold larger than that of docetaxel. The first-order peritoneal cavity-systemic circulation absorption rate constant of paclitaxel was 1/8 that of docetaxel. Docetaxel concentrations in free and solid tumors in the peritoneal cavity were higher than those of paclitaxel. The in vitro uptake of paclitaxel by AH130 cells was inhibited by Cremophor EL and Polysorbate-80. Docetaxel uptake was only slightly affected by these surfactants. These results indicated that Taxol scarcely released paclitaxel, while Taxotere easily released docetaxel, enabling its distribution to tumors disseminated in the peritoneal cavity.
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Authors
Yukio Kamijo, Chie Ito, Masaaki Nomura, Yoshimichi Sai, Ken-ichi Miyamoto,