Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116520 | Cancer Letters | 2009 | 6 Pages |
Abstract
Jumping translocation breakpoint protein (JTB) is suppressed in many cancers, implying it plays a role in the neoplastic transformation of cells. In order to explore the role of JTB in the carcinogenesis of liver, we used mammalian two-hybrid, co-immunoprecipitation, GST pull-down and laser scanning confocal to verify the interaction between HBs and JTB. According to the results, HBs interacts with JTB. In addition, we further determined that S region within HBs is sufficient for binding JTB. Overexpression of JTB conferred resistance to apoptosis induced by ultraviolet radiation, whereas this effect was compromised by the co-overexpression of HBs.
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Authors
Jin-Shui Pan, Jia-Yan Cai, Chen-Xi Xie, Fei Zhou, Zhi-Ping Zhang, Jing Dong, Hong-Zhi Xu, Hua-Xiu Shi, Jian-Lin Ren,