Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116525 | Cancer Letters | 2009 | 10 Pages |
Abstract
The role of AFP in the retinoic acid-RAR signaling pathway was investigated in human hepatoma Bel 7402 cells. The results showed that AFP and RAR-β were co-localized and interacted in cytoplasm. AFP may inhibit translocation of RAR-β into the nucleus via competitive binding to RAR-β with ATRA, which was reversed by AFP-siRNA transfection. Our data suggest that the ATRA resistance of Bel 7402 cells is at least in part attributable to their high level of cytoplasmic AFP. Thus, by counteracting the effect of AFP, it may be possible to increase the sensitivity of tumor cells to ATRA.
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Authors
Mengsen Li, Hui Li, Chaoying Li, Liyuan Guo, Han Liu, Sheng Zhou, Xinhua Liu, Zhuo Chen, Shuanglin Shi, Jiang Wei, Michael A. McNutt, Gang Li,