| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2116591 | Cancer Letters | 2009 | 6 Pages |
Abstract
BRMS1 and SUDS3 are related members of SIN3-HDAC chromatin remodeling complexes. We hypothesized that they might have overlapping functions and that SUDS3 over-expression could compensate for BRMS1 deficiency. SUDS3 expression was ubiquitous in seven breast cell lines, regardless of metastatic potential. SUDS3 over-expression in BRMS1-non-expressing metastatic cells did not suppress metastasis, motility, osteopontin secretion, or EGF receptor expression, phenotypes associated with BRMS1-mediated metastasis suppression. This study demonstrates functional differences for BRMS1 family members and highlights how the composition of SIN3-HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors.
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Authors
Alexandra C. Silveira, Douglas R. Hurst, Kedar S. Vaidya, Donald E. Ayer, Danny R. Welch,