| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2116632 | Cancer Letters | 2008 | 10 Pages |
Abstract
The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases’ and controls’ family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN∗2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Yunxia Feng, Jianzhong Zhang, Liping Dai, Jianying Zhang, Peng Wang, Jing Zang, Yuchun Li, Kaijuan Wang,