Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116714 | Cancer Letters | 2008 | 12 Pages |
Abstract
Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer.
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Authors
Ilse Novak-Hofer, Susan Cohrs, Jürgen Grünberg, Alexandra Friedli, Monika C. Schlatter, Marco Pfeifer, Peter Altevogt, P. August Schubiger,