Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116753 | Cancer Letters | 2007 | 10 Pages |
Abstract
Clinical observations suggest that hepatocyte growth factor (HGF) can promote invasion and metastasis in hepatocellular carcinoma. In this study, we found that HGF-stimulated invasion of SK-Hep-1 cells, together with increased expression of matrix metalloproteinase (MMP)-9. CHM-1 was identified from 2-phenyl-4-quinolone derivatives to potently inhibit HGF-induced cell invasion, proteolytic activity, and expression of MMP-9. CHM-1 significantly inhibited tyrosine autophosphorylation of c-Met induced by HGF. CHM-1 also suppressed HGF-induced Akt phosphorylation, and NF-κB activation, the downstream regulators of HGF/c-Met signaling, resulting in the inhibition of MMP-9. Thus, we suggest that CHM-1 is a potential therapeutic agent against tumor invasion.
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Authors
Shih-Wei Wang, Shiow-Lin Pan, Chieh-Yu Peng, Der-Yi Huang, An-Chi Tsai, Ya-Ling Chang, Jih-Hwa Guh, Sheng-Chu Kuo, Kuo-Hsiung Lee, Che-Ming Teng,