Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116807 | Cancer Letters | 2007 | 8 Pages |
Abstract
We detected aberrant Midkine (MK) expressions in human insulinoma and pancreatic cancer tissues by immunohistochemistry, revealing its potential role in tumorigenesis/carcinogenesis. With a nested-touchdown PCR program we were able to detect the tMK in all human tumor/cancer tissues and cancer/tumor cell lines. Detection of MK in the peripheral cells and precancerous lesions implies its potential for early cancer/tumor diagnosis. Furthermore, we have discovered two novel truncations of the MK, tMKB and tMKC, respectively, in the disease specimens. Our data not only provide an efficient methodology potentially for clinical application but also shed light on the molecular mechanism underlying the role for MK in tumorigenesis/carcinogenesis.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Ping Tao, Donghui Xu, Shuibin Lin, Gao-Liang Ouyang, Youde Chang, Qin Chen, Yuanyang Yuan, Xinming Zhuo, Qicong Luo, Jie Li, Baoan Li, Lingjuan Ruan, Qifu Li, Zhixing Li,