Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116816 | Cancer Letters | 2007 | 6 Pages |
Abstract
To evaluate whether the tumour suppressor gene, PPP2R1B, is involved in pathogenesis of hepatocellular carcinoma (HCC), reverse transcription-polymerase chain reaction (RT-PCR) and cDNA sequencing were performed. Eleven of 38 (29%) tumours and 1 of 34 (3%) corresponding non-tumour tissues showed coexpression of wild-type and aberrant mRNA. Various deletions were found in aberrant transcripts. Southern blot analysis did not show gene deletion in tumours, suggesting abnormal RNA splicing may be involved. These data suggest the possibility that aberrant transcripts of PPP2R1B might be associated with the development of HCC.
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Authors
Huei-Chi Chou, Chien-Hung Chen, Hsuan-Shu Lee, Cha-Ze Lee, Guan-Tarn Huang, Pei-Ming Yang, Po-Huang Lee, Jin-Chuan Sheu,