Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2116927 | Cancer Letters | 2006 | 5 Pages |
Abstract
There is increasing evidence that dose-response curve of genotoxic carcinogen is nonlinear and a practical threshold dose exists. However, little is known about differences in the dose-response relationship of genotoxic carcinogen among different strain rats. Herein, we showed that low doses of genotoxic carcinogen 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQx) had no effects on induction of liver glutathione S-transferase placental form (GST-P)-positive foci in both BN and F344 rats, and therefore demonstrated the existence of no-observed effect level for hepatocarcinogenicity of this genotoxic carcinogen irrespective of strains. These findings further support our notion that a practical threshold dose for MeIQx hepatocarcinogenicity exists in rats.
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Cancer Research
Authors
Min Wei, Taka-aki Hori, Toshio Ichihara, Hideki Wanibuchi, Keiichirou Morimura, Jin Seok Kang, Rawiwan Puatanachokchai, Shoji Fukushima,