Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2119685 | Differentiation | 2010 | 6 Pages |
Abstract
Human Wharton’s jelly-derived mesenchymal stromal cells (hWJ-MSCs) are capable of differentiating into neural and astroglia-like cell types. However, a reliable means of inducing the selective differentiation of hWJ-MSCs into oligodendrocyte progenitor cells (OPCs) in vitro has not yet been established. In this study, the OPC-like differentiation of hWJ-MSCs was characterized using and immunoblotting. The hWJ-MSC-derived OPC-like cells were able to secrete nerve growth factors and promote neurite outgrowth in vitro. These results show that hWJ-MSCs can be induced to differentiate into cells with the morphologic, phenotypic and functional characteristics of OPC-like cells.
Keywords
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Authors
Hong-Tian Zhang, Juan Fan, Ying-Qian Cai, Shu-Ju Zhao, Shan Xue, Jian-Hao Lin, Xiao-Dan Jiang, Ru-Xiang Xu,