Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2120341 | Drug Resistance Updates | 2015 | 8 Pages |
Abstract
The clag multigene family is strictly conserved in malaria parasites, but absent from neighboring genera of protozoan parasites. Early research pointed to roles in merozoite invasion and infected cell cytoadherence, but more recent studies have implicated channel-mediated uptake of ions and nutrients from host plasma. Here, we review the current understanding of this gene family, which appears to be central to host–parasite interactions and an important therapeutic target.
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Authors
Ankit Gupta, Girija Thiruvengadam, Sanjay A. Desai,