Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2124618 | European Journal of Cancer | 2007 | 6 Pages |
Abstract
Sulindac induces an increase in epithelial cell proliferation in the proximal colon of subjects with HNPCC. Since colorectal cancer predominantly arises in the proximal colon in HNPCC, these results cast doubts on the potential chemopreventive effects of sulindac in HNPCC.
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Authors
Fleur E.M. Rijcken, Harry Hollema, Ate G.J. van der Zee, Tineke van der Sluis, Wytske Boersma-van Ek, Jan H. Kleibeuker,