Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2125613 | European Journal of Cancer | 2007 | 6 Pages |
Abstract
Our investigations demonstrate for the first time that sensitizing G0 phase squamous cell carcinoma cells for docetaxel treatment is possible by prestimulation with target cytokines. Considering that up to 95% of tumor cells are in the resting (G0) phase of the cell cycle at the initiation of chemotherapy, prestimulation with EGF and serotonin could contribute to a synchronization of cancer cells. This would clearly enhance the cytotoxic effect.
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Cancer Research
Authors
Markus Hambek, Christian Werner, Mehran Baghi, Wolfgang Gstöttner, Rainald Knecht,