Article ID Journal Published Year Pages File Type
2129914 Experimental Cell Research 2016 12 Pages PDF
Abstract

•Carcinoma cells do not invade into non-neoplastic tissue.•Heart contains soluble factors that inhibit carcinoma cell migration and invasion.•Myomas can be lyophilized and rehydrated without loss of invasion promotion.•The use of myoma tissue in in vitro cancer studies is highly rational.

The invasion of carcinoma cells is a crucial feature in carcinogenesis. The penetration efficiency not only depends on the cancer cells, but also on the composition of the tumor microenvironment. Our group has developed a 3D invasion assay based on human uterine leiomyoma tissue. Here we tested whether human, porcine, mouse or rat hearts as well as porcine tongue t

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Authors
, , , , , , , , , , , , , ,