Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2130383 | Experimental Cell Research | 2014 | 9 Pages |
●miR-26a directly target ATM in GBM cells.●miR-26a enhances the radiosensitivity of GBM cells.●miR-26a could reduce the DNA repair capacity of GBM cells.
Glioblastoma multiforme (GBM) is notoriously resistant to radiation, and consequently, new radiosensitizers are urgently needed. MicroRNAs are a class of endogenous gene modulators with emerging roles in DNA repair. We found that overexpression of miR-26a can enhance radiosensitivity and reduce the DNA repair ability of U87 cells. However, knockdown miR-26a in U87 cells could act the converse manner. Mechanistically, this effect is mediated by direct targeting of miR-26a to the 3′UTR of ATM, which leads to reduced ATM levels and consequent inhibition of the homologous recombination repair pathway. These results suggest that miR-26a may act as a new radiosensitizer of GBM.