| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2130550 | Experimental Cell Research | 2013 | 10 Pages |
Abstract
⺠Epigallocatechin gallate (EGCG) plus sulforaphane (SFN) inhibit resistant cancer. ⺠This inhibition of resistant ovarian cancer cells causes G2/M arrest and apoptosis. ⺠EGCG and SFN treatment causes DNA damage to the ovarian cancer cells. ⺠These treatments also decrease hTERT and Bcl-2 expression in ovarian cancer cells. ⺠EGCG and SFN are effective in treating paclitaxel-resistant ovarian cancer cells.
Keywords
HDACSKOV3DNA methyltransferase 1Dnmt1PARPSFNEGCG3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromideDMSOMTTepigallocatechin gallateEnzyme-linked immunosorbent assayELISADimethyl sulfoxideOvarian cancerSulforaphanehistone deacetylasepolymerase chain reactionPCRPaclitaxelPropidium iodidePoly(ADP-ribose) polymerase
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Authors
Huaping Chen, Charles N Landen, Yuanyuan Li, Ronald D Alvarez, Trygve O Tollefsbol,