| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2132058 | Experimental Cell Research | 2008 | 9 Pages |
Abstract
Chromatin structure is not fixed. Instead, chromatin is dynamic and is subject to extensive developmental and age-associated remodeling. In some cases, this remodeling appears to counter the aging and age-associated diseases, such as cancer, and extend organismal lifespan. However, stochastic non-deterministic changes in chromatin structure might, over time, also contribute to the break down of nuclear, cell and tissue function, and consequently aging and age-associated diseases.
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Authors
John M. Sedivy, Gowrishankar Banumathy, Peter D. Adams,