Article ID Journal Published Year Pages File Type
2132657 Experimental Cell Research 2009 6 Pages PDF
Abstract

This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 should be considered a biomaker for cancers susceptible to IGF-IR targeting. In addition, I would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect of tumor suppressors, a sort of anti-p53 molecule.

Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Cancer Research
Authors
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