Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2132657 | Experimental Cell Research | 2009 | 6 Pages |
Abstract
This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 should be considered a biomaker for cancers susceptible to IGF-IR targeting. In addition, I would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect of tumor suppressors, a sort of anti-p53 molecule.
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Cancer Research
Authors
Renato Baserga,