Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2132771 | Experimental Cell Research | 2006 | 14 Pages |
Abstract
Death receptors such as the 55 kDa tumor necrosis factor (TNF) receptor (TNF-R55) or Fas can initiate both apoptotic (caspase-dependent) and caspase-independent routes to programmed cell death (PCD). Here, we demonstrate for the first time that the single murine receptor for (TNF)-related apoptosis-inducing ligand (mTRAIL-R2) can induce a caspase-independent form of PCD with necrosis-like features in addition to apoptosi
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Authors
Lutz Thon, Sabine Mathieu, Dieter Kabelitz, Dieter Adam,