| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2134266 | Experimental Hematology | 2011 | 19 Pages |
Abstract
These results demonstrate that SphK1 is upregulated in imatinib-resistant K562 cells by a pathway contingent on a phosphoinositide 3-kinase/AKT2/mammalian target of rapamycin signaling pathway. We propose that SphK1 plays an important role in development of acquired resistance to imatinib in chronic myeloid leukemia cell lines.
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Authors
Gabriella Marfe, Carla Di Stefano, Alessandra Gambacurta, Tiziana Ottone, Valentina Martini, Elisabetta Abruzzese, Luca Mologni, Paola Sinibaldi-Salimei, Paolo de Fabritis, Carlo Gambacorti-Passerini, Sergio Amadori, Raymond B. Birge,