Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A

Ex vivo culture of lin− cells for γ-retroviral transduction downregulates CXCR4 expression and markedly impairs homing and engraftment of murine lin− marrow in submyeloablated hosts. While inhibition of CD26 activity with DipA increases homing and engraftment of fresh lin− cells, DipA treatment does not improve homing and engraftment of cultured lin− marrow cells in submyeloablated congenic hosts.