| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2136446 | Leukemia Research | 2016 | 6 Pages |
•CD26 expression correlates with Rai’s clinical stage at diagnosis, β2-microglobulin concentration, LDH activity and ALC.•In B-CLL patients TTT is significantly and independently influenced by clinical disease stage according to Rai, LDH activity and CD26 expression on B-CLL cells.•CD26 expression correlates with Rai’s stage, β2-microglobulin, LDH and ALC.•CD26 expression does not correlate with patient’s gender, age and CD38 expression.•TTT is significantly influenced by Rai’s stage, LDH activity and CD26 expression.
A number of factors related to B-cell chronic lymphocytic leukemia (B-CLL) patients' prognosis have been identified. However, still some factors better reflecting disease activity in individual cases are explored. The study aimed to evaluate prognostic significance of dipeptidylpeptidase IV/CD26 expression on B-CLL cells and its relationship with other well established prognostic factors. The study included 94 patients with newly diagnosed B-CLL and involved analysis of clinical, laboratory, flow-cytometry and cytogenetic data. Detailed analysis showed that CD26 expression on B-CLL cells correlates with Rai’s clinical stage of the disease at diagnosis (p = 0.034), β2-microglobulin concentration (p = 0.012), lactic acid dehydrogenase activity (p = 0.045) and absolute lymphocytes’ count (p = 0.027) in the blood. The multivariate analysis revealed that time to treatment (TTT) was significantly influenced by Rai clinical stage, LDH activity in blood and CD26 expression on B-CLL cell’s. Moreover, in the multivariate analysis restricted to the group of patients with documented cytogenetic risk (n = 36) CD26 expression, Rai clinical stage and cytogenetic profile remained their independent impact on TTT. The results of our study indicate that the CD26 expression should be incorporated in B-CLL patients risk assessment along with well known prognostic factors, since it seems to have a relationship with the tumor mass and influences TTT.
