Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2136577 | Leukemia Research | 2014 | 6 Pages |
Abstract
Emerging studies suggest that the population of malignant cells found in human acute myelogenous leukemia (AML) arises from a rare population of leukemic stem cells (LSCs). A lot of investigators have reported the identification of cell surface markers, such as CD123. Here, we report the identification of N-cadherin and Tie2 as LSCs markers. Inoculation of CD34+CD38−CD123+N-cadherin+ and CD34+CD38−CD123+ Tie2+ population can induce leukemia in NOD/SCID mice. The leukemic blast cells from the primary leukemic mice could also induce leukemia in the secondary transplantation. These findings suggested that N-cadherin and Tie2 were the important markers that can assist in leukemia development.
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Authors
Shaowei Qiu, Yujiao Jia, Haiyan Xing, Tengteng Yu, Jing Yu, Pei Yu, Kejing Tang, Zheng Tian, Huijun Wang, Yingchang Mi, Qing Rao, Min Wang, Jianxiang Wang,