| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2136660 | Leukemia Research | 2014 | 4 Pages |
Abstract
Secondary acute lymphoblastic leukemia (sALL) following chemotherapy and/or radiotherapy of previous malignancies represents 2-10% of all cases of ALL. A 72-year-old female patient was diagnosed with acute lymphoblastic leukemia following chemotherapy for a diffuse large B cell lymphoma. Banding cytogenetics showed a t(t(5;11)(q23-31;q23) in 20 of the 21 metaphases examined and fluorescent in situ hybridization confirmed rearrangement of MLL. Long distance inverse-polymerase chain reaction revealed an in-frame fusion between 5â²MLL and 3â²PRRC1. Sixty-five cases of sALL associated with 11q23/MLL rearrangement, including 47 with a t(4;11)(q21;q23), were retrieved from the literature. Drug regimen used to treat the primary neoplasm was available for 54 patients; 52 had received a topoisomerase II inhibitor, known to induce MLL rearrangement.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Nathalie Douet-Guilbert, Jean-Richard Eveillard, Claus Meyer, Valérie Ugo, Marie-Josée Le Bris, Audrey Basinko, Frédéric Morel, Rolf Marschalek, Marc De Braekeleer,