Geriatric assessment in older patients with acute myeloid leukemia: A retrospective study of associated treatment and outcomes

We explored whether geriatric assessment variables predicted mortality in addition to known prognostic factors in 101 patients aged ≥65 with newly diagnosed AML. Baseline comorbidity score (HR = 1.92; 95%CI 1.18–3.11), difficulty with strenuous activity (HR = 2.18; 95%CI 1.19–4.00), and pain (HR = 2.17; 95%CI 1.19–3.97) were independent prognostic factors for greater risk of death in a multivariable model that included cytogenetic risk group. They remained independent predictors in the subset of patients with baseline ECOG PS 0-1. Our results support the use of geriatric assessment to better predict prognosis in older patients with AML, even among those with excellent functional status.