Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137000 | Leukemia Research | 2014 | 9 Pages |
Abstract
Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3−/− B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3−/− B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.
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Authors
Shanique K.E. Edwards, Anand Desai, Yan Liu, Carissa R. Moore, Ping Xie,