Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137163 | Leukemia Research | 2012 | 7 Pages |
Abstract
Cytogenetics and molecular cytogenetics of 1466 Chinese patients with de novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1;19), +8, 12qâ, +21, +22 and high hyperdiploidy with 51-65 chromosomes, and lower incidences of t(9;22) and â5/5qâ than adult ones (all p < 0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients.
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Authors
Xin Li, Juan Li, Yanjie Hu, Wei Xie, Wen Du, Wei Liu, Xiaoqing Li, Xiangjun Chen, Hongrui Li, Junfeng Wang, Lannan Zhang, Shiang Huang,