Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137173 | Leukemia Research | 2012 | 8 Pages |
Abstract
We investigate the relative importance of the different mechanisms of Adriamycin, an anthracycline, and their interrelations, in particular the link between cell cycle arrest, cell death, and generation of reactive oxygen species (ROS) that is suspected to be the origin of cardiotoxic side-effects. We introduced a lifetime fluorescence based technology and used videomicrofluorometry, two efficient analytical methods. We show that depending on the doses and time after incubation, ADR will not reach the same compartments (nucleus, mitochondria, cytosol) in the cells, having consequences on the production of ROS, growth arrest pathways and cell death pathways.
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Authors
Julien Savatier, Tareck Rharass, Christophe Canal, Adam Gbankoto, Jean Vigo, Jean-Marie Salmon, Anne-Cécile Ribou,