Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137189 | Leukemia Research | 2013 | 5 Pages |
Abstract
We evaluated the prognostic value of BAALC expression in 86 patients with acute promyelocytic leukemia (APL).At 10 years, the overall survival (OS) was 66% in all patients and 75% in patients who achieved a complete remission (CR). Patients in the BAALClow group showed an OS of 87% as compared to 60% in the BAALChigh group (p = 0.019). This difference was more pronounced in treatment responders (92% vs. 70%; p = 0.035). In multivariate analyses low BAALC expression retained its prognostic relevance.In conclusion, BAALC expression analysis might be useful in further risk stratification in APL patients.
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Authors
Florian Nolte, Anna Hecht, Mark Reinwald, Daniel Nowak, Verena Nowak, Benjamin Hanfstein, Andreas Faldum, Thomas Büchner, Karsten Spiekermann, Cristina Sauerland, Wolf-Karsten Hofmann, Eva Lengfelder,