Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137282 | Leukemia Research | 2011 | 5 Pages |
Abstract
A cohort of 338 patients diagnosed with myeloproliferative neoplasms was investigated by conventional cytogenetics and evaluated for the presence of the JAK2 V617F mutation. A t(1;9)(p10;q10) in addition to two extra der(1;9)(q10;p10) chromosomes was observed in two patients of essential thrombocythemia that transformed to acute myelogenous leukemia or to myelofibrosis. These findings suggest that the presence of extra derivative chromosomes der(1q;9p) in combination with the JAK2 V617F mutation may play a role in the progression of myeloproliferative neoplasms and supports the use of cytogenetics in the follow-up of the disease.
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Authors
Annette Leon, John F. Staropoli, Jesus M. Hernandez, Janina A. Longtine, Frank C. Kuo, Paola Dal Cin,