Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137327 | Leukemia Research | 2011 | 11 Pages |
Abstract
To ascertain genomic alterations associated with Imatinib resistance in chronic myeloid leukaemia, we performed high resolution genomic analysis of CD34+ cells from 25 Imatinib (IM) resistant and 11 responders CML patients. Using patients’ T-cells as reference, we found significant association between number of acquired cryptic copy number alterations (CNA) and disease phase (p = 0.036) or loss of IM response for patients diagnosed in chronic phase (CP) (p = 0.04). Recurrent cryptic losses were identified on chromosomes 7, 12 and 13. On chromosome 7, recurrent deletions of the IKZF1 locus were detected, for the first time, in 4 patients in CP.
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Authors
Sami Joha, Véronique Dauphin, Frédéric Leprêtre, Sélim Corm, Franck E. Nicolini, Christophe Roumier, Olivier Nibourel, Nathalie Grardel, Véronique Maguer-Satta, Thierry Idziorek, Martin Figeac, Jean-Luc Laï, Bruno Quesnel, Gabriel Etienne,