Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137331 | Leukemia Research | 2011 | 5 Pages |
Abstract
This study evaluates the incidence and prognostic impact of aberrant methylation of 25 tumor suppressor genes in 40 patients with RARS, a MDS subtype, by methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assay. Methylation of at least one gene was detected in 18 patients (45%). The genes methylated were CDKN2B (20%), RASSF1 (18%), RARB (10%), CDH13 (7.5%) and FHIT (5%). Patients with at least one methylated gene had a significantly shorter OS than patients without methylated genes. Aberrant methylation is a frequent event in patients with RARS as in patients with high-risk MDS appears to confer a worse prognosis.
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Authors
Ana Valencia, José Cervera, Esperanza Such, Mariam Ibañez, Inés Gómez, Irene Luna, Leonor Senent, Silvestre Oltra, Miguel A. Sanz, Guillermo F. Sanz,