| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2137472 | Leukemia Research | 2011 | 7 Pages |
Abstract
Our previous research has revealed that binding of the chemokine CCL25 to the CCR9 provides chemotactic cues guiding leukemic cells to specific tissues and organs. The RhoA-ROCK pathway might be involved in cancer migration. The purpose of this study was to explore the role of the RhoA-ROCK-MLC axis in leukemic cell migration following exposure to CCL25. The results showed that CCL25 could increase the amount of the GTPase RhoA and activate MLC in MOLT4 cells in a time-dependent manner. C3 exoenzyme and Y-27632 could block MOLT4 cell migration and chemotaxis. Thus, the RhoA-ROCK-MLC axis might play an important role in MOLT4 cell metastasis induced by CCL25.
Keywords
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Cancer Research
Authors
Li Zhang, Beibei Yu, Meng Hu, Zhan Wang, Dongying Liu, Xiaoling Tong, Jun Leng, Beibei Zhou, Yi Hu, Ranran Wu, Qianshan Ding, Qiuping Zhang,