Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137515 | Leukemia Research | 2012 | 7 Pages |
Abstract
NF-κB plays a major role in the pathology of multiple myeloma. Here, we intended to investigate the regulating effect of cardamonin on NF-κB in myeloma cells. We found for the first time that cardamonin suppressed viability and induced apoptosis of myeloma cells. Cardamonin activated caspase-3 and PARP and suppressed the expression of various anti-apoptotic proteins. We discovered that NF-κB was repressed by cardamonin through suppression of IKK expression and IκBα phosphorylation. Furthermore, the expression of NF-κB-regulated gene products ICAM-1, COX-2 and VEGF was down-regulated by cardamonin. These results suggest that cardamonin blocks NF-κB pathway in human multiple myeloma cells.
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Authors
You Qin, Chun-Yan Sun, Fu-Rong Lu, Xiang-Rong Shu, Di Yang, Lei Chen, Xiao-Mei She, Nicholas Miller Gregg, Tao Guo, Yu Hu,