| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2137585 | Leukemia Research | 2010 | 8 Pages |
Abstract
We investigated the transformation from pDCs to mDCs in a pDC line (PMDC05) which was established from a patient with pDC leukemia in our laboratory. PMDC05 cells were separated into two fractions according to the expression of BDCA1 and CD123. BDCA1−CD123+ cells were found to be pDC-like cells by their morphology, surface phenotypes, mRNA expression and the function. In addition, BDCA1−CD123+ cells were demonstrated to have a proliferating capacity and revealed the ability to transform to BDCA1+CD123− cells which showed mDC-like properties. Our data demonstrated the possibility of transformation from pDCs to mDCs in human DC lineage.
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Authors
Norihiro Watanabe, Miwako Narita, Akie Yamahira, Takeshi Nakamura, Nozomi Tochiki, Anri Saitoh, Masami Kaji, Shigeo Hashimoto, Tatsuo Furukawa, Ken Toba, Ichiro Fuse, Yoshifusa Aizawa, Masuhiro Takahashi,