Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137611 | Leukemia Research | 2011 | 6 Pages |
Abstract
Mutations of isocitrate dehydrogenase 1 (IDH1) have recently been reported in acute myeloid leukemia (AML). However, the characteristics of IDH1-mutated AML are still not known clearly. We analyzed 416 Chinese AML patients and found 28 patients (6.7%) carried this mutation. One homozygous IDH1 mutant in AML was found. The IDH1 mutations were associated with NPM1 mutations (P = 0.043) and could coexist with recurrent transcription factor aberrations including AML1-ETO (6/50), PML-RARα (3/77) and CBFβ-MYH11 (1/15). For AML with AML1-ETO fusion gene, IDH1mut patients may have worse disease-free survival (DFS) than IDH1wild-type patients.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Yiqun Zhang, Hui Wei, Min Wang, Lei Huai, Yingchang Mi, Yizhi Zhang, Dong Lin, Bingcheng Liu, Wei Li, Chunlin Zhou, Qing Rao, Jianxiang Wang,