Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137904 | Leukemia Research | 2010 | 6 Pages |
Abstract
This study evaluates the mRNA expression profile of genes TIMP1, TIMP2, MMP2 and MMP9 in diagnostic bone marrow samples from 134 consecutive ALL children by real-time quantitative PCR. A significant association was observed between higher expression levels of MMP9 and low risk group and absence of extramedullary infiltration and higher expression levels of TIMP2 and MMP2 with T-ALL. TIMP1 gene expression values higher than the median were associated with a significantly lower 5-year event free-survival in univariable (PÂ =Â 0.04) and multivariable analysis (PÂ =Â 0.01). Our data address new information in the complex interaction of the migration/adhesion genes and childhood ALL.
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Authors
Carlos Alberto Scrideli, Maria Angélica Abdala Cortez, José Andres Yunes, Rosane Gomes de Paula Queiróz, Elvis Terci Valera, Juliana França da Mata, Silvia Regina Caminada Toledo, Priscila Pavoni-Ferreira, Maria Lúcia de Martino Lee,