Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137906 | Leukemia Research | 2010 | 4 Pages |
Abstract
Real-time quantitative reverse transcriptase polymerase chain reaction method was established for detecting the expression levels of WT1 gene and WT1+17AA isoforms in 226 acute myeloid leukemia (AML) bone marrow (BM) cells. The results showed that WT1 gene was 2-3 logarithms expressed more in AML BM cells at initial diagnosis or relapse than in normal BM cells (p < 0.001), with predominant WT1+17AA isoforms expression (the ratio of WT1+17AA/WT1 more than 0.50). Interestingly the ratio of WT1+17AA/WT1 was statistically higher in relapsed AMLs than in initially diagnosed (p = 0.01), speculating that WT1+17AA isoforms might participate in AML relapse.
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Authors
Weiying Gu, Shaoyan Hu, Zixing Chen, Guoqiang Qiu, Jiannong Cen, Bai He, Jun He, Wei Wu,