Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137953 | Leukemia Research | 2008 | 12 Pages |
Abstract
Lithocholic acid (LCA) acetate induced the differentiation of human leukemia cells. Treatment with a combination of LCA acetate and cotylenin A, an inducer of the differentiation of leukemia cells, was more effective than that with LCA acetate or cotylenin A alone at inducing monocytic differentiation. LCA acetate activated mitogen-activated protein kinase (MAPK) before inducing differentiation. Cotylenin A did not activate MAPK, suggesting that cotylenin A has a different mode of action. The cooperative effects of LCA acetate and cotylenin A on inducing differentiation were, at least partly, due to the enhancement of LCA acetate-induced MAPK activation by cotylenin A.
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Authors
Akiyoshi Horie, Miho Akimoto, Hiroto Tsumura, Makoto Makishima, Takeshi Taketani, Seiji Yamaguchi, Yoshio Honma,