Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2137968 | Leukemia Research | 2011 | 5 Pages |
Abstract
Patients with multiple myeloma (MM) are at relatively high risk of developing thromboembolic event (TEE), especially during treatment with immnomodulatory agents. We characterized coagulation profiles and evaluate the incidence of TEE associated with the combination therapy of bortezomib–thalidomide–dexamethasone (VTD) in Chinese patients with newly diagnosed MM. The results indicated that the platelet count and platelet aggregation induced by the agonists were decreased after a short exposure to bortezomib in vivo. The incidence of TEE was low in VTD therapy for an overall rate of 3%. We do not recommend routine thromboprophylaxis for VTD therapy in Chinese patients with MM.
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Authors
Yunfeng Shen, Xin Zhou, Zhi Wang, Guohua Yang, Yuanqiang Jiang, Chao Sun, Jing Wang, Yi Tong, Hongfeng Guo,