Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138105 | Leukemia Research | 2009 | 5 Pages |
Abstract
10-20% of APL patients relapse and the challenge remains to early identify these patients to improve survival rate. We report PML-RARα transcript detection by RQ-PCR in 260 consecutive APL patients (n = 970 samples). 223 patients with samples of sufficient RNA quality to demonstrate they reached molecular remission were monitored for MRD. During follow-up, 38 of these patients were tested positive for PML-RARα mRNA. 13 out of the 38 patients (34%) effectively developed hematological relapse. In the first positive sample, specific PML-RARα NCN thresholds over which, or under which, patients could effectively be predicted to relapse or not, were identified and subsequently validated in a second cohort.
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Authors
Bruno Cassinat, Stéphane de Botton, Charikleia Kelaidi, Lionel Ades, Fabien Zassadowski, Isabelle Guillemot, Marie-Helene Schlageter, Emmanuel Raffoux, Jean-Luc Harousseau, Olivier Legrand, Martine Escoffre-Barbe, Oumedaly Reman, Martine Gardembas,