| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2138116 | Leukemia Research | 2009 | 6 Pages |
Abstract
Oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of tumor suppressor p53. Our previous study revealed that the expression of iASPP in acute leukemia (AL) patients was higher than that of normal control which implied that iASPP might play an important role in the pathogenesis and/or disease progression of AL. In this study, the iASPP expression was blocked by RNA interference (RNAi) in two leukemic cell lines, Nalm6 and K562, to explore the effects of iASPP on leukemia cells. The results indicated that down-regulation of endogenous iASPP increased p53-dependent apoptosis of leukemia cells. Thus, iASPP could be a molecular target in leukemia therapy.
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Authors
Hang Liu, Min Wang, Shiyong Diao, Qing Rao, Xinwei Zhang, Haiyan Xing, Jianxiang Wang,