Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138117 | Leukemia Research | 2009 | 6 Pages |
Abstract
All-trans retinoic acid (ATRA) induces granulocytic maturation of WEHI-3B D+ leukemia cells and LiCl enhances this maturation, while WEHI-3B Dâ cells are non-responsive to ATRA. Transfection of SCL, expressed in Dâ but absent in D+ cells, into D+ cells, caused resistance to ATRA, while transfection of GATA-1 into D+ cells produced resistance to the combination of ATRA and LiCl. SCL expression in D+ cells did not induce the expression of c-Kit, a putative target gene for SCL. LiCl, known to inhibit some kinases by displacing Mg2+, did not affect tyrosine kinase activity of the cytoplasmic domain of c-Kit.
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Authors
Kimiko Ishiguro, Anna M. Rice, Kevin P. Rice, Alan C. Sartorelli,