Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
2138122 | Leukemia Research | 2009 | 6 Pages |
Abstract
We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases. Submicroscopic deletions of chromosome 22q11 were observed in 28 cases (15%), and the frequency of these deletions was second only to loss of the 13q14 region, the most common genomic aberration in CLL. Oligonucleotide-based array CGH analysis showed that the 22q11 deletions ranged in size from 0.34Â Mb up to â¼1Â Mb. The minimally deleted region included the ZNF280A, ZNF280B, GGTLC2, and PRAME genes. Quantitative real-time PCR revealed that ZNF280A, ZNF280B, and PRAME mRNA expression was significantly lower in the 22q11 deletion cases compared to non-deleted cases.
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Authors
Shelly R. Gunn, Aswani R. Bolla, Lynn L. Barron, Mercedes E. Gorre, Mansoor S. Mohammed, David W. Bahler, Clemens H.M. Mellink, Marinus H.J. van Oers, Michael J. Keating, Alessandra Ferrajoli, Kevin R. Coombes, Lynne V. Abruzzo, Ryan S. Robetorye,