| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2138163 | Leukemia Research | 2010 | 6 Pages |
Abstract
The recently demonstrated reliance of glycolytic cancer cells on trans-plasma membrane electron transport (tPMET) for survival raises the question of its suitability as a target for anticancer drug development. In this study, the effects of several new and known compounds on proliferation, tPMET activity and NAD(P)H intrinsic fluorescence in human myelogenous leukemic cell lines were investigated. The whole data confirm the importance of tPMET in leukemic cell survival and suggest this activity as a new potential anti-leukemic target.
Keywords
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Biochemistry, Genetics and Molecular Biology
Cancer Research
Authors
Cecilia Prata, Carole Grasso, Stefano Loizzo, Francesco Vieceli Dalla Sega, Cristiana Caliceti, Laura Zambonin, Diana Fiorentini, Gabriele Hakim, Michael V. Berridge, Laura Landi,