| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 2138288 | Leukemia Research | 2010 | 4 Pages |
Abstract
Most chromosomal rearrangements including the mixed lineage leukemia (MLL) gene are manifested as leukemia and predict a poor prognosis. Although more than 50 MLL-rearrangement partners are characterized, MLL-related leukemogenesis remains to be understood. Here we report a case of a 3-year old boy bearing a novel MLL-rearrangement with the suppressor of actin mutations 1-like (SACM1L) gene in the absence of leukemia. Bone marrow cells harboring the MLL–SACM1L rearrangement appeared during chemotherapy for acute lymphoblastic leukemia with hyperdiploidy and were continuously detected over 7 years without clonal expansion.
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Authors
Takeshi Mori, Noriyuki Nishimura, Daiichiro Hasegawa, Keiichiro Kawasaki, Yoshiyuki Kosaka, Kazuko Uchide, Tomoko Yanai, Akira Hayakawa, Yasuhiro Takeshima, Hisahide Nishio, Masafumi Matsuo,